The Portuguese brought a formidable record from Porto with him, but he was unable to begin the season on a winning note as Stoke held out for a goalless draw.
Villas-Boas was part of Jose Mourinho's backroom staff when he began Chelsea's recent run of silverware by lifting the Premier League trophy in 2005, and the new man is making no secret of what he will consider success to be come May.
He said of his first match: "I would have enjoyed it better if I had won it but I came up short in terms of the result. I was away from it (the Premier League) a couple of years but I never stopped following it. There's so many beautiful things in this game.
"The challenge this season is to get back the Premier League title. It's a point away from home, at Stoke, and it's a difficult place. Last season we finished second and we are here because we want to finish first."
Villas-Boas was playing his cards close to his chest in terms of possible forays into the transfer market, saying only: "There's plenty of time still to make those decisions. I think the market will get extremely frenetic in the last week."
After an even first half where Chelsea dealt well with Stoke's long throws and corners, the Blues took control at the start of the second half.
However, they could not translate their possession into goals, with John Obi Mikel and Nicolas Anelka both seeing shots well saved by Asmir Begovic.
It was a point gained as far as Stoke boss Tony Pulis was concerned, although it came at a cost with injuries to Matthew Etherington and Rory Delap.
Winger Etherington was due to have an X-ray on a shoulder injury on Sunday night after leaving the field in obvious pain while Delap suffered a recurrence of a hamstring problem.
One major positive for Pulis, though, was the performance of centre-back Jonathan Woodgate on his Premier League debut for the club.
The former England man is aiming to prove himself again after an injury-ravaged spell at Tottenham, while Pulis will also soon be able to call on the services of Matthew Upson, another free signing following the end of his contract at West Ham.
"Woody has been fantastic since he came into the club," said the Potters boss. "That's the third clean sheet we've got and he's played a big part in it.
"And he'll be a great role model for the young players we've got in the team. We need experience and Matty Upson and Woody will give us that."
Source: Team Talk
Source: Team Talk